Blar i forfatter "Ludwig, Friedrich-Alexander"

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    • Development of 8f-labeled radiotracers for pet imaging of the adenosine a2a receptor: Synthesis, radiolabeling and preliminary biological evaluation 

      Lai, Thu Hang; Schröder, Susann; Toussaint, Magali; Dukić-Stefanović, Sladjana; Kranz, Mathias; Ludwig, Friedrich-Alexander; Fischer, Steffen; Steinbach, Jörg; Deuther-Conrad, Winnie; Brust, Peter; Moldovan, Rareş-Petru (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-25)
      The adenosine A<sub>2A</sub> receptor (A<sub>2A</sub>R) represents a potential therapeutic target for neurodegenerative diseases. Aiming at the development of a positron emission tomography (PET) radiotracer to monitor changes of receptor density and/or occupancy during the A<sub>2A</sub>R-tailored therapy, we designed a library of fluorinated analogs based on a recently published lead compound ...

    • Preclinical incorporation dosimetry of [18F]FACH—A novel 18F-labeled MCT1/MCT4 lactate transporter inhibitor for imaging cancer metabolism with PET 

      Sattler, Bernhard; Kranz, Mathias; Wenzel, Barbara; Jain, Nalin T.; Moldovan, Rareş-Petru; Toussaint, Magali; Deuther-Conrad, Winnie; Ludwig, Friedrich-Alexander; Teodoro, Rodrigo; Sattler, Tatjana; Sadeghzadeh, Masoud; Sabri, Osama; Brust, Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-26)
      Overexpression of monocarboxylate transporters (MCTs) has been shown for a variety of human cancers (e.g., colon, brain, breast, and kidney) and inhibition resulted in intracellular lactate accumulation, acidosis, and cell death. Thus, MCTs are promising targets to investigate tumor cancer metabolism with positron emission tomography (PET). Here, the organ doses (ODs) and the effective dose (ED) of ...

    • Radiosynthesis and biological investigation of a novel fluorine-18 labeled benzoimidazotriazine- based radioligand for the imaging of phosphodiesterase 2A with positron emission tomography 

      Ritawidya, Rien; Wenzel, Barbara; Teodoro, Rodrigo; Toussaint, Magali; Kranz, Mathias; Deuther-Conrad, Winnie; Dukić-Stefanović, Sladjana; Ludwig, Friedrich-Alexander; Scheunemann, Matthias; Brust, Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-15)
      A specific radioligand for the imaging of cyclic nucleotide phosphodiesterase 2A (PDE2A) via positron emission tomography (PET) would be helpful for research on the physiology and disease-related changes in the expression of this enzyme in the brain. In this report, the radiosynthesis of a novel PDE2A radioligand and the subsequent biological evaluation were described. Our prospective compound ...

    • Sigma-1 receptor positron emission tomography: A new molecular imaging approach using (S)-(-)-[18F]fluspidine in glioblastoma 

      Toussaint, Magali; Deuther-Conrad, Winnie; Kranz, Mathias; Fischer, Steffen; Ludwig, Friedrich-Alexander; Juratli, Tareq A.; Patt, Marianne; Wünsch, Bernhard; Schackert, Gabriele; Sabri, Osama; Brust, Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-06)
      Glioblastoma multiforme (GBM) is the most devastating primary brain tumour characterised by infiltrative growth and resistance to therapies. According to recent research, the sigma-1 receptor (sig1R), an endoplasmic reticulum chaperone protein, is involved in signaling pathways assumed to control the proliferation of cancer cells and thus could serve as candidate for molecular characterisation of ...